Article
Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2007
Barbareschi Mattia, Buttitta Fiamma, Felicioni Lara, Cotrupi Sabrina, Barassi Fabio, Del Grammastro Maela, Ferro Antonella, Dalla Palma Paolo, Galligioni Enzo, Marchetti Antonio
Abstract excerpt
PURPOSE: In breast cancer, the PIK3CA gene is frequently mutated at "hotspots" in exons 9 and 20, corresponding to the helical and kinase domains, respectively. We decided to investigate the association of PIK3CA mutations with pathologic features and clinical outcome in a large series of patients with breast cancer. EXPERIMENTAL DESIGN: Frozen samples from 163 consecutive patients were analyzed for PIK3CA...
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