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Article

PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2009

Ogino Shuji, Nosho Katsuhiko, Kirkner Gregory J, Shima Kaori, Irahara Natsumi, Kure Shoko, Chan Andrew T, Engelman Jeffrey A, Kraft Peter, Cantley Lewis C, Giovannucci Edward L, Fuchs Charles S

Abstract excerpt

PURPOSE: PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the prognostic role of PIK3CA mutation in colon cancer. PATIENTS AND METHODS: Using 450 resectable colon cancers (stage I to III) in two independent prospective cohorts, we detected PIK3CA mutation in 82 tumors (18%) by pyrosequencing. Cox proportional hazards...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19237633
DOI: 10.1200/JCO.2008.18.6544
PMCID: PMC2659340

Genes

PIK3CA
KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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