Article
Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial.
Journal of the National Cancer Institute - 4 Dec 2013
Ogino Shuji, Liao Xiaoyun, Imamura Yu, Yamauchi Mai, McCleary Nadine J, Ng Kimmie, Niedzwiecki Donna, Saltz Leonard B, Mayer Robert J, Whittom Renaud, Hantel Alexander, Benson Al B, Mowat Rex B, Spiegelman Donna, Goldberg Richard M, Bertagnolli Monica M, Meyerhardt Jeffrey A, Fuchs Charles S
Abstract excerpt
BACKGROUND: Somatic mutations in PIK3CA (phosphatidylinositol-4,5-bisphosphonate 3-kinase [PI3K], catalytic subunit alpha gene) activate the PI3K-AKT signaling pathway and contribute to pathogenesis of various malignancies, including colorectal cancer. METHODS: We examined associations of PIK3CA oncogene mutation with relapse, survival, and treatment efficacy in 627 stage III colon carcinoma case subjects within...
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