Article
Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity.
Experimental gerontology - 1 Nov 2011
Rose Giuseppina, Crocco Paolina, D'Aquila Patrizia, Montesanto Alberto, Bellizzi Dina, Passarino Giuseppe
Abstract excerpt
The brown fat specific UnCoupling Protein 1 (UCP1) is involved in thermogenesis, a process by which energy is dissipated as heat in response to cold stress and excess of caloric intake. Thermogenesis has potential implications for body mass control and cellular fat metabolism. In fact, in humans, the variability of the UCP1 gene is associated with obesity, fat gain and metabolism. Since regulation of metabolism...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.