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Article

Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis.

Biogerontology - 1 Jun 2017

Dato Serena, De Rango Francesco, Crocco Paolina, Passarino Giuseppe, Rose Giuseppina

Abstract excerpt

The rate of telomere-shortening has been widely reported as a marker of risk for age-related conditions and mortality in human population. Genetic, environmental and stochastic factors have been shown to influence telomere attrition. In particular oxidative stress has been reported to play an important role on the process. Uncoupling proteins (UCPs) are among the most important regulators of cellular metabolism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28281015
DOI: 10.1007/s10522-017-9690-z

Genes

UCP2
UCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Pleiotropic effects of UCP2-UCP3 variability on leucocyte telomere length and glucose homeostasis.PMID 28281015Read ↗

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Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity.Semantic proximity Read ↗

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Shortened leukocyte telomere length in type 2 diabetes mellitus: genetic polymorphisms in mitochondrial uncoupling proteins and telomeric pathwaysSemantic proximity Read ↗

Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases.Semantic proximity Read ↗

Variation in the UCP2-UCP3 gene cluster predicts the development of type 2 diabetes in healthy middle-aged men.Semantic proximity Read ↗

Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study.Semantic proximity Read ↗

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Single nucleotide polymorphisms linked to mitochondrial uncoupling protein genes UCP2 and UCP3 affect mitochondrial metabolism and healthy aging in female nonagenarians.Semantic proximity Read ↗

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