Article
The rs2516839 variation of USF1 gene is associated with 4-year mortality of nonagenarian women: The Vitality 90+ study.
Annals of human genetics - 1 Jan 2019
Ozsait-Selcuk B, Komurcu-Bayrak E, Jylhä M, Luukkaala T, Perola M, Kristiansson K, Mononen N, Hurme M, Kähönen M, Goebeler S, Laaksonen R, Hervonen A, Erginel-Unaltuna N, Karhunen P J, Lehtimäki T
Abstract excerpt
Upstream transcription factor 1 (USF1) regulates the transcription of many genes related to cell and organism survival processes such as stress and immune response, regulation of cellular senesce, and carcinogenesis. In this study, our aim was to investigate the effect of USF1 single nucleotide variations (SNVs) on longevity in the Vitality 90+ study, a population-based study of nonagenarians (90 ±1 years of age)...
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