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Article

The Role of Nonshivering Thermogenesis Genes on Leptin Levels Regulation in Residents of the Coldest Region of Siberia.

International journal of molecular sciences - 28 Apr 2021

Nikanorova Alena A, Barashkov Nikolay A, Pshennikova Vera G, Nakhodkin Sergey S, Gotovtsev Nyurgun N, Romanov Georgii P, Solovyev Aisen V, Kuzmina Sargylana S, Sazonov Nikolay N, Fedorova Sardana A

Abstract excerpt

Leptin plays an important role in thermoregulation and is possibly associated with the microevolutionary processes of human adaptation to a cold climate. In this study, based on the Yakut population (n = 281 individuals) living in the coldest region of Siberia (t°minimum -71.2 °C), we analyze the serum leptin levels and data of 14 single nucleotide polymorphisms (SNPs) of 10 genes (UCP1, UCP2, UCP3, FNDC5,...

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Identifiers

PMID: 33925025
DOI: 10.3390/ijms22094657
PMCID: PMC8124869

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