Article
Frequency and significance of the A-->G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort.
European journal of clinical investigation - 1 Sept 1999
Schäffler A, Palitzsch K D, Watzlawek E, Drobnik W, Schwer H, Schölmerich J, Schmitz G
Abstract excerpt
BACKGROUND: The recently described A-->G (-3826) point mutation within the distal region of the UCP-1 promoter is possibly involved in the development of obesity, diabetes and related metabolic disorders. It was the aim of this study to examine the allelic frequency and the prevalence of the thre...
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