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Article

Reversibility of Tau-related cognitive defects in a regulatable FTD mouse model.

Journal of molecular neuroscience : MN - 1 Nov 2011

Sydow Astrid, Van der Jeugd Ann, Zheng Fang, Ahmed Tariq, Balschun Detlef, Petrova Olga, Drexler Dagmar, Zhou Lepu, Rune Gabriele, Mandelkow Eckhard, D'Hooge Rudi, Alzheimer Christian, Mandelkow Eva-Maria

Abstract excerpt

The accumulation of proteins such as Tau is a hallmark of several neurodegenerative diseases, e.g., frontotemporal dementia (FTD). So far, many mouse models of tauopathies have been generated by the use of mutated or truncated human Tau isoforms in order to enhance the amyloidogenic character of...

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PMID: 21822709
DOI: 10.1007/s12031-011-9604-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-21822709-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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