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Article

The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy.

The Journal of biological chemistry - 26 Oct 2007

Eckermann Katrin, Mocanu Maria-Magdalena, Khlistunova Inna, Biernat Jacek, Nissen Astrid, Hofmann Anne, Schönig Kai, Bujard Hermann, Haemisch Andreas, Mandelkow Eckhard, Zhou Lepu, Rune Gabriele, Mandelkow Eva-Maria

Abstract excerpt

Neurofibrillary lesions are characteristic for a group of human diseases, named tauopathies, which are characterized by prominent intracellular accumulations of abnormal filaments formed by the microtubule-associated protein Tau. The tauopathies are accompanied by abnormal changes in Tau protein, including pathological conformation, somatodendritic mislocalization, hyperphosphorylation, and aggregation, whose...

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PMID: 17716969
DOI: 10.1074/jbc.M705282200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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