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Article

'Prion-like' propagation of mouse and human tau aggregates in an inducible mouse model of tauopathy.

Neuro-degenerative diseases - 1 Jan 2010

Sydow Astrid, Mandelkow Eva-Maria

Abstract excerpt

BACKGROUND: Aggregates of the tau protein are a hallmark of Alzheimer's and several other neurodegenerative diseases. Various transgenic mouse models have been generated to study the aggregation process. Since wild-type tau is highly soluble and does not aggregate readily, most models make use of tau mutations that occur in human frontotemporal dementias and are more prone to aggregate. These mouse models show...

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Identifiers

PMID: 20160454
DOI: 10.1159/000283479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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