Article
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Feb 2011
Sydow Astrid, Van der Jeugd Ann, Zheng Fang, Ahmed Tariq, Balschun Detlef, Petrova Olga, Drexler Dagmar, Zhou Lepu, Rune Gabriele, Mandelkow Eckhard, D'Hooge Rudi, Alzheimer Christian, Mandelkow Eva-Maria
Abstract excerpt
This report describes the behavioral and electrophysiological analysis of regulatable transgenic mice expressing mutant repeat domains of human Tau (Tau(RD)). Mice were generated to express Tau(RD) in two forms, differing in their propensity for β-structure and thus in their tendency for aggregation ("pro-aggregant" or "anti-aggregant") (Mocanu et al., 2008). Only pro-aggregant mice show pronounced changes...
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