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Article

Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology.

The FEBS journal - 1 Sept 2013

Hochgräfe Katja, Sydow Astrid, Mandelkow Eva-Maria

Abstract excerpt

Accumulation of amyloidogenic proteins such as Tau is a hallmark of neurodegenerative diseases including Alzheimer disease and fronto-temporal dementias. To link Tau pathology to cognitive impairments and defects in synaptic plasticity, we created four inducible Tau transgenic mouse models with expression of pro- and anti-aggregant variants of either full-length human Tau (hTau40/ΔK280 and hTau40/ΔK280/PP) or the...

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Identifiers

PMID: 23517246
DOI: 10.1111/febs.12250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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