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Article

Acute pyelonephritis and renal scarring are caused by dysfunctional innate immunity in mCxcr2 heterozygous mice.

Kidney international - 1 Nov 2011

Svensson Majlis, Yadav Manisha, Holmqvist Bo, Lutay Nataliya, Svanborg Catharina, Godaly Gabriela

Abstract excerpt

The CXCR1 receptor and chemokine CXCL8 (IL-8) support neutrophil-dependent clearance of uropathogenic Escherichia coli from the urinary tract. CXCR1 is reduced in children prone to pyelonephritis, and heterozygous hCXCR1 polymorphisms are more common in this patient group than in healthy individuals, strongly suggesting a disease association. Since murine CXCR2 (mCXCR2) is functionally similar to human CXCR1, we...

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Source

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Identifiers

PMID: 21814172
DOI: 10.1038/ki.2011.257
PMCID: PMC3257042

Genes

CXCR1
CXCL8
CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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