Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance

29 Jul 2021

Abstract excerpt

Infectious diseases continually pose global medical challenges. The transcription factor GATA2 establishes gene networks and defines cellular identity in hematopoietic stem/progenitor cells and in progeny committed to specific lineages. GATA2-haploinsufficient patients exhibit a spectrum of immunodeficiencies associated with bacterial, viral, and fungal infections. Despite accumulating clinical knowledge of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis Research Advances
Share to Immunodeficiency and Autoimmune Disorders
Share to Pneumocystis jirovecii pneumonia detection and treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34471858
DOI: 10.1016/j.isci.2021.102836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearancePMID 34471858Read ↗

Haematopoietic and immune defects associated with GATA2 mutation.Semantic proximity Read ↗

Loss of HSC stemness identity is associated with exhaustion and hyporesponsiveness in GATA2 deficiency syndromeSemantic proximity Read ↗

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.Semantic proximity Read ↗

GATA2 deficiency syndrome: A decade of discoverySemantic proximity Read ↗

GATA2 deficiency.Semantic proximity Read ↗

Pathogenic GATA2 genetic variants utilize an obligate enhancer mechanism to distort a multilineage differentiation program.Semantic proximity Read ↗

Genetic variation and inflammation intersections: GATA2- and RUNX1-linked mechanisms of blood pathogenesis.Semantic proximity Read ↗

Role of the pioneer transcription factor GATA2 in health and disease.Semantic proximity Read ↗

Human GATA2 mutations and hematologic disease: how many paths to pathogenesis?Semantic proximity Read ↗

Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during agingSemantic proximity Read ↗

The spectrum of GATA2 deficiency syndrome.Semantic proximity Read ↗

GATA 2 Deficiency: Focus on Immune System ImpairmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.