Article
A genetic basis of susceptibility to acute pyelonephritis.
PloS one - 5 Sept 2007
Lundstedt Ann-Charlotte, McCarthy Shane, Gustafsson Mattias C U, Godaly Gabriela, Jodal Ulf, Karpman Diana, Leijonhufvud Irene, Lindén Carin, Martinell Jeanette, Ragnarsdottir Bryndis, Samuelsson Martin, Truedsson Lennart, Andersson Björn, Svanborg Catharina
Abstract excerpt
BACKGROUND: For unknown reasons, urinary tract infections (UTIs) are clustered in certain individuals. Here we propose a novel, genetically determined cause of susceptibility to acute pyelonephritis, which is the most severe form of UTI. The IL-8 receptor, CXCR1, was identified as a candidate gene when mIL-8Rh mutant mice developed acute pyelonephritis (APN) with severe tissue damage. METHODS AND FINDINGS: We...
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