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Article

Leptin Receptor q223r Polymorphism Influences Clostridioides difficile Infection-Induced Neutrophil CXCR2 Expression in an Interleukin-1β Dependent Manner.

Frontiers in cellular and infection microbiology - 1 Jan 2021

Horrigan Olivia, Jose Shinsmon, Mukherjee Anindita, Sharma Divya, Huber Alexander, Madan Rajat

Abstract excerpt

Neutrophils are key first-responders in the innate immune response to C. difficile infection (CDI) and play a central role in disease pathogenesis. Studies have clearly shown that tissue neutrophil numbers need to be tightly regulated for optimal CDI outcomes: while excessive colonic neutrophilia is associated with severe CDI, neutrophil depletion also results in worse outcomes. However, the biological mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33718269
DOI: 10.3389/fcimb.2021.619192
PMCID: PMC7946998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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