Article
CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival.
Science translational medicine - 20 Jan 2016
Swamydas Muthulekha, Gao Ji-Liang, Break Timothy J, Johnson Melissa D, Jaeger Martin, Rodriguez Carlos A, Lim Jean K, Green Nathaniel M, Collar Amanda L, Fischer Brett G, Lee Chyi-Chia Richard, Perfect John R, Alexander Barbara D, Kullberg Bart-Jan, Netea Mihai G, Murphy Philip M, Lionakis Michail S
Abstract excerpt
Systemic Candida albicans infection causes high morbidity and mortality and is now the leading cause of nosocomial bloodstream infection in the United States. Neutropenia is a major risk factor for poor outcome in infected patients; however, the molecular factors that mediate neutrophil trafficking and effector function during infection are poorly defined. Using a mouse model of systemic candidiasis, we found...
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