Article
TLR- and CXCR1-dependent innate immunity: insights into the genetics of urinary tract infections.
European journal of clinical investigation - 1 Oct 2008
Ragnarsdóttir B, Fischer H, Godaly G, Grönberg-Hernandez J, Gustafsson M, Karpman D, Lundstedt A C, Lutay N, Rämisch S, Svensson M L, Wullt B, Yadav M, Svanborg C
Abstract excerpt
The susceptibility to urinary tract infection (UTI) is controlled by the innate immune response and Toll like receptors (TLRs) are the sentinels of this response. If productive, TLR4 signalling may initiate the symptomatic disease process. In the absence of TLR4 signalling the infected host instead develops an asymptomatic carrier state. The activation of mucosal TLR4 is also influenced by the properties of the...
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