Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prion-like acceleration of a synucleinopathy in a transgenic mouse model.

Neurobiology of aging - 1 Sept 2012

Mougenot Anne-Laure, Nicot Simon, Bencsik Anna, Morignat Eric, Verchère Jérémy, Lakhdar Latefa, Legastelois Stéphane, Baron Thierry

Abstract excerpt

Our aim in this study was to investigate experimentally the possible in vivo transmission of a synucleinopathy, using a transgenic mouse model (TgM83) expressing the human A53T mutated α-synuclein. Brain homogenates from old TgM83 mice showing motor clinical signs due to the synucleinopathy and containing insoluble and phosphorylated (pSer129) α-synuclein were intracerebrally inoculated in young TgM83 mice. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Intermediate Filament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Movement Disorders

Share to Phosphorylation

Share to Prion Diseases

Share to Serine

Share to Survival Analysis

Source

Identifiers

PMID: 21813214
DOI: 10.1016/j.neurobiolaging.2011.06.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prion-like acceleration of a synucleinopathy in a transgenic mouse model.PMID 21813214Read ↗

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Semantic proximity Read ↗

'Prion-like' propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum.Semantic proximity Read ↗

Transmission of multiple system atrophy prions to transgenic miceSemantic proximity Read ↗

Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathySemantic proximity Read ↗

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Semantic proximity Read ↗

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.Semantic proximity Read ↗

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.Semantic proximity Read ↗

Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease.Semantic proximity Read ↗

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Semantic proximity Read ↗

Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophySemantic proximity Read ↗

Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice.Semantic proximity Read ↗

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrilsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.