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Article

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.

Journal of virology - 15 Jan 2017

Ayers Jacob I, Brooks Mieu M, Rutherford Nicola J, Howard Jasie K, Sorrentino Zachary A, Riffe Cara J, Giasson Benoit I

Abstract excerpt

Misfolded α-synuclein (αS) is hypothesized to spread throughout the central nervous system (CNS) by neuronal connectivity leading to widespread pathology. Increasing evidence indicates that it also has the potential to invade the CNS via peripheral nerves in a prion-like manner. On the basis of the effectiveness following peripheral routes of prion administration, we extend our previous studies of CNS...

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Identifiers

PMID: 27852849
DOI: 10.1128/JVI.02095-16
PMCID: PMC5215322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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