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Article

Transmission of multiple system atrophy prions to transgenic mice

11 Nov 2013

Abstract excerpt

Prions are proteins that adopt alternative conformations, which become self-propagating. Increasing evidence argues that prions feature in the synucleinopathies that include Parkinson's disease, Lewy body dementia, and multiple system atrophy (MSA). Although TgM83(+/+) mice homozygous for a mutant A53T α-synuclein transgene begin developing CNS dysfunction spontaneously at ∼10 mo of age, uninoculated TgM83(+/-)...

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PMID: 24218576
DOI: 10.1073/pnas.1318268110

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