Article
Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.
Acta neuropathologica communications - 24 Nov 2021
Macdonald Jennifer A, Chen John L, Masuda-Suzukake Masami, Schweighauser Manuel, Jaunmuktane Zane, Warner Thomas, Holton Janice L, Grossman Annabelle, Berks Richard, Lavenir Isabelle, Goedert Michel
Abstract excerpt
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83). The same was the case when cerebellar extracts from a case of multiple system atrophy with type II α-synuclein filaments were administered intraperitoneally, intravenously or intramuscularly. We observed...
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