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Article

Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy

4 Feb 2020

Abstract excerpt

Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we sought to characterize the spread of α-synuclein in a transgenic mouse model of MSA prion propagation to support drug discovery programs for synucleinopathies. Brain...

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PMID: 32017806
DOI: 10.1371/journal.ppat.1008222

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