Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

20 May 2019

Abstract excerpt

α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central nervous system (CNS) inoculation studies using either in vitro polymerized αS fibrils or in vivo derived lysates containing αS aggregates to induce the progressive spread of αS inclusion pathology in animal disease models have supported the notion that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neurological diseases and metabolism
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31109378
DOI: 10.1186/s40478-019-0733-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrilsPMID 31109378Read ↗

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.Semantic proximity Read ↗

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.Semantic proximity Read ↗

'Prion-like' propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum.Semantic proximity Read ↗

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds.Semantic proximity Read ↗

Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophySemantic proximity Read ↗

Loss of Tau Expression Attenuates Neurodegeneration Associated With α-SynucleinopathySemantic proximity Read ↗

Transmission of multiple system atrophy prions to transgenic miceSemantic proximity Read ↗

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA.Semantic proximity Read ↗

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.Semantic proximity Read ↗

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in miceSemantic proximity Read ↗

α-Synuclein Oligomers Induce a Unique Toxic Tau StrainSemantic proximity Read ↗

The A53E α-synuclein pathological mutation demonstrates reduced aggregation propensity in vitro and in cell culture.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.