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Article

Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2014

Sacino Amanda N, Brooks Mieu, Thomas Michael A, McKinney Alex B, Lee Sooyeon, Regenhardt Robert W, McGarvey Nicholas H, Ayers Jacob I, Notterpek Lucia, Borchelt David R, Golde Todd E, Giasson Benoit I

Abstract excerpt

It has been hypothesized that α-synuclein (αS) misfolding may begin in peripheral nerves and spread to the central nervous system (CNS), leading to Parkinson disease and related disorders. Although recent data suggest that αS pathology can spread within the mouse brain, there is no direct evidence for spread of disease from a peripheral site. In the present study, we show that hind limb intramuscular (IM)...

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Identifiers

PMID: 25002524
DOI: 10.1073/pnas.1321785111
PMCID: PMC4115570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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