Article
Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice.
Journal of neuropathology and experimental neurology - 1 Dec 2014
Bencsik Anna, Muselli Letizia, Leboidre Mikael, Lakhdar Latifa, Baron Thierry
Abstract excerpt
Alpha-synuclein is a key protein in Parkinson disease (PD) and dementia with Lewy bodies. It is found in Lewy bodies in the brains of PD patients and has been reported in the peripheral nervous system in postmortem tissues from PD patients and in biopsies from patients in the preclinical phase of PD. Here, we used a transgenic mouse model of human synucleinopathies expressing the A53T mutant α-synuclein (TgM83)...
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