Article

Investigating the neuroprotective effect of AAV-mediated β-synuclein overexpression in a transgenic model of synucleinopathy

2018-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases characterized by inclusions mainly composed of α-synuclein (α-syn) aggregates. The objective of this study was to investigate if β-synuclein (β-syn) overexpression could have beneficial effects by inhibiting the aggregation of α-syn. The M83 transgenic mouse is a model of synucleinopathy, which develops sev...

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Literature Corpus work: ba30b5fb-bc2c-594e-8a8c-043de2cd3ea9
DOI: 10.1101/300822

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