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Article

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein.

Acta neuropathologica communications - 26 Nov 2015

Bernis Maria E, Babila Julius T, Breid Sara, Wüsten Katharina Annick, Wüllner Ullrich, Tamgüney Gültekin

Abstract excerpt

INTRODUCTION: Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that are characterized by the intracellular accumulation of alpha-synuclein containing aggregates. Recent increasing evidence suggests that Parkinson's disease and MSA pathology spread throughout the nervous system in a spatiotemporal fashion, possibly by prion-like propagation of alpha-synuclein positive...

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Identifiers

PMID: 26612754
DOI: 10.1186/s40478-015-0254-7
PMCID: PMC4660655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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