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Article

'Prion-like' propagation of the synucleinopathy of M83 transgenic mice depends on the mouse genotype and type of inoculum.

Journal of neurochemistry - 1 Oct 2017

Sargent Dorian, Verchère Jérémy, Lazizzera Corinne, Gaillard Damien, Lakhdar Latifa, Streichenberger Nathalie, Morignat Eric, Bétemps Dominique, Baron Thierry

Abstract excerpt

The M83 transgenic mouse is a model of human synucleinopathies that develops severe motor impairment correlated with accumulation of the pathological Ser129-phosphorylated α-synuclein (α-synP ) in the brain and spinal cord. M83 disease can be accelerated by intracerebral inoculation of brain extracts from sick M83 mice. This has also recently been described using peripheral routes, injecting recombinant preformed...

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PMID: 28771723
DOI: 10.1111/jnc.14139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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