Article
Runs of homozygosity do not influence survival to old age.
PloS one - 1 Jan 2011
Kuningas Maris, McQuillan Ruth, Wilson James F, Hofman Albert, van Duijn Cornelia M, Uitterlinden André G, Tiemeier Henning
Abstract excerpt
Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH...
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