Article
No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2011
Sims Rebecca, Dwyer Sarah, Harold Denise, Gerrish Amy, Hollingworth Paul, Chapman Jade, Jones Nicola, Abraham Richard, Ivanov Dobril, Pahwa Jaspreet Singh, Moskvina Valentina, Dowzell Kimberley, Thomas Charlene, Stretton Alexandra, Lovestone Simon, Powell John, Proitsi Petroula, Lupton Michelle K, Brayne Carol, Rubinsztein David C, Gill Michael, Lawlor Brian, Lynch Aoibhinn, Morgan Kevin, Brown Kristelle S, Passmore Peter A, Craig David, McGuiness Bernadette, Todd Stephen, Johnston Janet A, Holmes Clive, Mann David, Smith A David, Love Seth, Kehoe Patrick G, Hardy John, Mead Simon, Fox Nick, Rossor Martin, Collinge John, Livingston Gill, Bass Nicholas J, Gurling Hugh, McQuillin Andrew, Jones Lesley, Holmans Peter A, O'Donovan Michael, Owen Michael J, Williams Julie
Abstract excerpt
We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no...
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