Article

Ancestry-dependent Enrichment of Deleterious Homozygotes in Runs of Homozygosity

2018-08-01

Abstract excerpt

Runs of homozygosity (ROH) are important genomic features that manifest when an individual inherits two haplotypes that are identical-by-descent. Their length distributions are informative about population history, and their genomic locations are useful for mapping recessive loci contributing to both Mendelian and complex disease risk. We have previously shown that ROH, and especially long ROH that are likely the...

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Literature Corpus work: 1ec354e3-c0e4-5731-a61f-6ec6563b98da
DOI: 10.1101/382721

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