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Article

Long runs of homozygosity are enriched for deleterious variation.

American journal of human genetics - 11 Jul 2013

Szpiech Zachary A, Xu Jishu, Pemberton Trevor J, Peng Weiping, Zöllner Sebastian, Rosenberg Noah A, Li Jun Z

Abstract excerpt

Exome sequencing offers the potential to study the population-genomic variables that underlie patterns of deleterious variation. Runs of homozygosity (ROH) are long stretches of consecutive homozygous genotypes probably reflecting segments shared identically by descent as the result of processes...

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Identifiers

PMID: 23746547
DOI: 10.1016/j.ajhg.2013.05.003
PMCID: PMC3710769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23746547-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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