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Article

Genomic runs of homozygosity record population history and consanguinity.

PloS one - 15 Nov 2010

Kirin Mirna, McQuillan Ruth, Franklin Christopher S, Campbell Harry, McKeigue Paul M, Wilson James F

Abstract excerpt

The human genome is characterised by many runs of homozygous genotypes, where identical haplotypes were inherited from each parent. The length of each run is determined partly by the number of generations since the common ancestor: offspring of cousin marriages have long runs of homozygosity (ROH), while the numerous shorter tracts relate to shared ancestry tens and hundreds of generations ago. Human populations...

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Identifiers

PMID: 21085596
DOI: 10.1371/journal.pone.0013996
PMCID: PMC2981575

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