Article
IFNG genotype and sex interact to influence the risk of childhood asthma.
The Journal of allergy and clinical immunology - 1 Sept 2011
Loisel Dagan A, Tan Zheng, Tisler Christopher J, Evans Michael D, Gangnon Ronald E, Jackson Daniel J, Gern James E, Lemanske Robert F, Ober Carole
Abstract excerpt
BACKGROUND: Asthma is a complex disease characterized by sex-specific differences in incidence, prevalence, and severity, but little is known about the molecular basis of these sex-based differences. OBJECTIVE: To investigate the genetic architecture of sex differences in asthma risk, we evaluated (1) associations between polymorphisms in the IFNG gene and childhood-onset asthma in combined and sex-specific...
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