Article
Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages.
The Journal of allergy and clinical immunology - 1 Aug 2016
Schieck Maximilian, Schouten Jan P, Michel Sven, Suttner Kathrin, Toncheva Antoaneta A, Gaertner Vincent D, Illig Thomas, Lipinski Simone, Franke Andre, Klintschar Michael, Kalayci Omer, Sahiner Umit M, Birben Esra, Melén Erik, Pershagen Göran, Freidin Maxim B, Ogorodova Ludmila M, Granell Raquel, Henderson John, Brunekreef Bert, Smit Henriëtte A, Vogelberg Christian, von Berg Andrea, Bufe Albrecht, Heinzmann Andrea, Laub Otto, Rietschel Ernst, Simma Burkhard, Genuneit Jon, Jonigk Danny, Postma Dirkje S, Koppelman Gerard H, Vonk Judith M, Timens Wim, Boezen H Marike, Kabesch Michael
Abstract excerpt
BACKGROUND: Asthma is a disease affecting more boys than girls in childhood and more women than men in adulthood. The mechanisms behind these sex-specific differences are not yet understood. OBJECTIVE: We analyzed whether and how genetic factors contribute to sex-specific predisposition to childhood-onset asthma. METHODS: Interactions between sex and polymorphisms on childhood asthma risk were evaluated in the...
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