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Article

Association between polymorphisms on chromosome 17q12-q21 and rhinovirus-induced interferon responses.

The Journal of allergy and clinical immunology - 1 Aug 2024

Regis Eteri, Fontanella Sara, Curtin John A, Pinot de Moira Angela, Edwards Michael R, Murray Clare S, Simpson Angela, Johnston Sebastian L, Custovic Adnan

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) in genes on chromosome 17q12-q21 are associated with childhood-onset asthma and rhinovirus-induced wheeze. There are few mechanistic data linking chromosome 17q12-q21 to wheezing illness. OBJECTIVE: We investigated whether 17q12-q21 risk alleles were associated with impaired interferon responses to rhinovirus. METHODS: In a population-based birth cohort of...

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Identifiers

PMID: 38494094
DOI: 10.1016/j.jaci.2024.03.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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