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Article

Interleukin-11 drives early lung inflammation during Mycobacterium tuberculosis infection in genetically susceptible mice.

PloS one - 1 Jan 2011

Kapina Marina A, Shepelkova Galina S, Avdeenko Vadim G, Guseva Anna N, Kondratieva Tatiana K, Evstifeev Vladimir V, Apt Alexander S

Abstract excerpt

IL-11 is multifunctional cytokine whose physiological role in the lungs during pulmonary tuberculosis (TB) is poorly understood. Here, using in vivo administration of specific antibodies against IL-11, we demonstrate for the first time that blocking IL-11 diminishes histopathology and neutrophilic infiltration of the lung tissue in TB-infected genetically susceptible mice. Antibody treatment decreased the...

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Identifiers

PMID: 21789190
DOI: 10.1371/journal.pone.0021878
PMCID: PMC3137601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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