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Mice genetically inactivated in interleukin‐17<scp>A</scp> receptor are defective in long‐term control of <i><scp>M</scp>ycobacterium tuberculosis</i> infection

30 May 2013

Abstract excerpt

Interleukin-17A (IL-17A), a pro-inflammatory cytokine acting on neutrophil recruitment, is known to play an important role during Mycobacterium tuberculosis infection, but the role of IL-17A receptor signalling in immune defence against this intracellular pathogen remains poorly documented. Here we have analysed this signalling using C57BL/6 mice genetically inactivated in the IL-17 receptor A subunit...

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PMID: 23721367
DOI: 10.1111/imm.12130

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