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Article

Neutrophils exacerbate tuberculosis infection in genetically susceptible mice.

Tuberculosis (Edinburgh, Scotland) - 1 Jul 2015

Yeremeev Vladimir, Linge Irina, Kondratieva Tatiana, Apt Alexander

Abstract excerpt

Mice of the I/St inbred strain genetically hyper-susceptible to TB infection and prone to form neutrophil-abundant necrotic lung lesions and relatively resistant mice of the C57BL/6 (B6) strain were infected with 100 CFU of M. tuberculosis H37Rv. To verify the role of neutrophils in TB immunity, we selectively depleted neutrophils from infected mice with highly specific 1A8 anti-Ly6G antibodies at day 2 and 6...

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Identifiers

PMID: 25935122
DOI: 10.1016/j.tube.2015.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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