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Article

STAT1 knockout mice are highly susceptible to pulmonary mycobacterial infection.

The Tohoku journal of experimental medicine - 1 Jan 2004

Sugawara Isamu, Yamada Hiroyuki, Mizuno Satoru

Abstract excerpt

This study was designed to determine the roles of STAT1 protein in defense against mycobacterial infection. Airborne infection of STAT1 knockout (KO) mice with a Mycobacterium tuberculosis Kurono strain induced multiple necrotic lesions in lungs, spleen and liver, while that in wild-type (WT) mice did not. The STAT1 KO mice succumbed to mycobacterial infection by the 35th day after infection. Compared with the...

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Source

Identifiers

PMID: 14738323
DOI: 10.1620/tjem.202.41

Genes

STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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