Article
Analysis of the lung transcriptome in Mycobacterium tuberculosis-infected mice reveals major differences in immune response pathways between TB-susceptible and resistant hosts.
Tuberculosis (Edinburgh, Scotland) - 1 Mar 2013
Shepelkova Galina, Pommerenke Claudia, Alberts Rudi, Geffers Robert, Evstifeev Vladimir, Apt Alexander, Schughart Klaus, Wilk Esther
Abstract excerpt
Using whole genome microarrays, we compared changes in gene expression patterns in the lungs of TB-resistant A/Sn and TB-susceptible I/St mice at day 14 following infection with Mycobacterium tuberculosis H37Rv. Analyses of differentially expressed genes for representation of gene ontology terms and activation of regulatory pathways revealed interstrain differences in antigen presentation, NK, T and B cell...
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