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Article

Advances on the Role and Applications of Interleukin-1 in Tuberculosis.

mBio - 21 Dec 2021

Silvério Diogo, Gonçalves Rute, Appelberg Rui, Saraiva Margarida

Abstract excerpt

Interleukin-1 (IL-1) is a key player in the immune response to pathogens due to its role in promoting inflammation and recruiting immune cells to the site of infection. In tuberculosis (TB), tight regulation of IL-1 responses is critical to ensure host resistance to infection while preventing immune pathology. In the mouse model of Mycobacterium tuberculosis infection, both IL-1 absence and overproduction result...

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Identifiers

PMID: 34809460
DOI: 10.1128/mBio.03134-21
PMCID: PMC8609357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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