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Article

Endogenous IL-11 signaling is essential in Th2- and IL-13-induced inflammation and mucus production.

American journal of respiratory cell and molecular biology - 1 Dec 2008

Lee Chun Geun, Hartl Dominik, Matsuura Hiroshi, Dunlop Felicity M, Scotney Pierre D, Fabri Louis J, Nash Andrew D, Chen Ning-Yuan, Tang Chu-Yan, Chen Qingsheng, Homer Robert J, Baca Manuel, Elias Jack A

Abstract excerpt

IL-11 and IL-11 receptor (R)alpha are induced by Th2 cytokines. However, the role(s) of endogenous IL-11 in antigen-induced Th2 inflammation has not been fully defined. We hypothesized that IL-11, signaling via IL-11Ralpha, plays an important role in aeroallergen-induced Th2 inflammation and mucus metaplasia. To test this hypothesis, we compared the responses induced by the aeroallergen ovalbumin (OVA) in...

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Identifiers

PMID: 18617680
DOI: 10.1165/rcmb.2008-0053OC
PMCID: PMC2586049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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