Article

Interleukin-1 receptor antagonist is a conserved early factor for exacerbating tuberculosis susceptibility

2023-11-01

Abstract excerpt

<h4>Summary</h4> Mycobacterium tuberculosis ( Mtb ) causes 1.25 million deaths a year. However, tuberculosis (TB) pathogenesis remains poorly understood and is not fully recapitulated in standard mouse models. Here we find that gene signatures from three different Mtb -susceptible mouse models predict active TB disease in humans significantly better than a signature from resistant C57BL/6 (B6) mice. Conserved a...

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Literature Corpus work: adcb7df2-a9b9-55be-b620-cecc6a30a944
DOI: 10.1101/2023.10.27.564420

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