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Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection

3 Jul 2018

Abstract excerpt

Abstract Tuberculosis ranks as one of the world’s deadliest infectious diseases causing more than a million casualties annually. IL10 inhibits the function of Th1 type cells, and IL10 deficiency has been associated with an improved resistance againstMycobacterium tuberculosisinfection in a mouse model. Here, we utilizedM. marinuminfection in the zebrafish (Danio rerio) as a model for studying Il10 in the host...

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PMID: 29985419
DOI: 10.1038/s41598-018-28511-w

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