Article
γδ T cells protect against lung fibrosis via IL-22.
The Journal of experimental medicine - 27 Sept 2010
Simonian Philip L, Wehrmann Fabian, Roark Christina L, Born Willi K, O'Brien Rebecca L, Fontenot Andrew P
Abstract excerpt
Inflammation-induced pulmonary fibrosis (PF) leads to irreversible loss of lung function and is a predictor of mortality in numerous lung diseases. Why some subjects with lung inflammation but not others develop PF is unclear. In a mouse model of hypersensitivity pneumonitis that progresses to lung fibrosis upon repeated exposure to the ubiquitous microorganism Bacillus subtilis, γδ T cells expand in the lung and...
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