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Article

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

Cell - 22 Jul 2011

Bermejo Rodrigo, Capra Thelma, Jossen Rachel, Colosio Arianna, Frattini Camilla, Carotenuto Walter, Cocito Andrea, Doksani Ylli, Klein Hannah, Gómez-González Belén, Aguilera Andrés, Katou Yuki, Shirahige Katsuhiko, Foiani Marco

Abstract excerpt

Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. Examining checkpoint-dependent mechanisms controlling fork stability, we find that fork reversal and dormant origin firing due to checkpoint defects are rescued in checkpoint mutants lacking THO, TREX-2, or inner-basket nucleoporins. Gene gating tethers transcribed genes to the nuclear periphery...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21784245
DOI: 10.1016/j.cell.2011.06.033
PMCID: PMC3160733

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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