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Article

The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.

Molecular and cellular biology - 1 Oct 2009

Gómez-González Belén, Felipe-Abrio Irene, Aguilera Andrés

Abstract excerpt

Cotranscriptional R-loops are formed in yeast mutants of the THO complex, which functions at the interface between transcription and mRNA export. Despite the relevance of R-loops in transcription-associated recombination, the mechanisms by which they trigger recombination are still elusive. In order to understand how R-loops compromise genome stability, we have analyzed the genetic interaction of THO with 26...

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Identifiers

PMID: 19651896
DOI: 10.1128/MCB.00402-09
PMCID: PMC2747986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants.PMID 19651896Read ↗

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MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflictsSemantic proximity Read ↗

Defective nucleotide excision repair in yeast hpr1 and tho2 mutants.Semantic proximity Read ↗

R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX.Semantic proximity Read ↗

A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants.Semantic proximity Read ↗

Genes with internal repeats require the THO complex for transcription.Semantic proximity Read ↗

A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.Semantic proximity Read ↗

A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination.Semantic proximity Read ↗

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